MyBioSource.com's BCL-2 Mouse mAb (9A4) is a Mouse monoclonal antibody. The BCL-2 Mouse mAb (9A4) Antibody was generated using BCL2, and BCL2 apoptosis regulator as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Western Blot.
Description
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)